There are six primary Nanto Sei Ken masters, the Nanto Rokusei Ken (南斗六聖拳, Six Sacred Fists of Nanto), to correspond to the six stars in the Nanto Roku Sei constellation. Each member of the Rokusei is destined to follow the star they represent, and each fate was awakened at its own time independent of the other Rokusei. Originally each of the six masters was a guard at each of the six gates of the emperor's palace. When Yuda betrayed the Nanto Roku Sei Ken by joining Raoh, the Nanto stars went into disarray, summoning Hokuto to restore order.
- Junsei: Shin - Nanto Koshū Ken
- Gisei: Rei - Nanto Suichō Ken
- Yōsei: Yuda - Nanto Kōkaku Ken
- Jinsei: Shū - Nanto Hakurō Ken
- Shōsei: Souther - Nanto Hōō Ken
- Jibosei: Yuria - Nanto Saigo no Shō